The ravages inflicted on ecosystems and human communities, especially those of frontline First Peoples, by the brutally exploitative extractive system that dominates the global economy, threaten to unravel the entire web of life. The challenge of our time is to quickly reverse that ecocidal trajectory, and one of the best places to look for effective alternative models is in the deep wisdom of traditional Indigenous cultures who learned over millennia to work with the natural world with an attitude of reverent and respectful reciprocity to meet human needs while ensuring the environment’s ongoing health. In this session three inspiring leaders working to implement various forms of Indigenous ecological science in partnerships with university, state and local partners share their perspectives and experiences. With Nina Simons, author of Nature, Culture & the Sacred and Bioneers’ co-founder; deeply respected longtime activist and educator Jeannette Armstrong, Ph.D., Syilx Okanagan Nation, cofounder Enowkin Centre; dynamic young leader in salmon restoration/dam removal struggles on the Klamath River, Sammy Gensaw III, Yurok, co-founder, Ancestral Guard; and Niko Alexandre, co-founder of the Shelterwood Collective, which brings together Black, Indigenous and LGBTQ people in a land-based, community-building project that is implementing TEK methods in their fields and forests.